Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype
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چکیده
منابع مشابه
Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype.
Separation of chemical and physical carcinogenesis into the stages of initiation (mutation) and promotion (selection) established that incipient neoplastic cells could persist in the organism indefinitely without expression. Spontaneous mutations associated with cancer also lie dormant in untreated normal tissue. Without selection, there is no tumor development. Experiments in cell culture show...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0800747105